Through Screens

Decoding directional genetic dependencies through orthogonal CRISPR/Cas screens

1. Department of Microbiology and Immunology; Diabetes Center at UCSF, WM Keck Center for Noncoding RNAs, University of California, San Francisco, San Francisco, California, USA. 2. Institute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, and Chan-Zuckerberg Biohub, San Francisco, California, USA. 3. Helen Diller Family Compre...

Identification of cell cycle-targeting microRNAs through genome-wide screens

By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening m...

Crystallization Screens Crystallization Optimization Cryo Screens Phasing

Urban Screens – The Urbane Potential of Public Screens for Interaction

Within a time frame of about ten years, experimental (interactive) media installations and performances have gained recognition as new art forms in public space. Artworks explore the interconnectedness of public space, interaction, and new media. Urban Screens investigates how the growing infrastructure of dynamic digital displays in urban space, currently dominated by commercial forces, can be...

Designing zebrafish chemical screens.

The zebrafish is proving to be highly amenable to in vivo small molecule screening. With a growing number of screens successfully completed, a rich interface is being created between disciplines that have historically used zebrafish (e.g., embryology and genetics) and disciplines focused on small molecules (e.g., chemistry and pharmacology). Navigating this interface requires consideration of t...